A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters
Identifieur interne : 002281 ( Main/Exploration ); précédent : 002280; suivant : 002282A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters
Auteurs : Youngik Yang [États-Unis] ; Kenneth Nephew [États-Unis] ; Sun Kim [Corée du Sud]Source :
- BMC Bioinformatics [ 1471-2105 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
DNA methylation is essential for normal development and differentiation and plays a crucial role in the development of nearly all types of cancer. Aberrant DNA methylation patterns, including genome-wide hypomethylation and region-specific hypermethylation, are frequently observed and contribute to the malignant phenotype. A number of studies have recently identified distinct features of genomic sequences that can be used for modeling specific DNA sequences that may be susceptible to aberrant CpG methylation in both cancer and normal cells. Although it is now possible, using next generation sequencing technologies, to assess human methylomes at base resolution, no reports currently exist on modeling cell type-specific DNA methylation susceptibility. Thus, we conducted a comprehensive modeling study of cell type-specific DNA methylation susceptibility at three different resolutions: CpG dinucleotides, CpG segments, and individual gene promoter regions.
Using a k-mer mixture logistic regression model, we effectively modeled DNA methylation susceptibility across five different cell types. Further, at the segment level, we achieved up to 0.75 in AUC prediction accuracy in a 10-fold cross validation study using a mixture of k-mers.
The significance of these results is three fold: 1) this is the first report to indicate that CpG methylation susceptible "segments" exist; 2) our model demonstrates the significance of certain k-mers for the mixture model, potentially highlighting DNA sequence features (k-mers) of differentially methylated, promoter CpG island sequences across different tissue types; 3) as only 3 or 4 bp patterns had previously been used for modeling DNA methylation susceptibility, ours is the first demonstration that 6-mer modeling can be performed without loss of accuracy.
Url:
DOI: 10.1186/1471-2105-13-S3-S15
PubMed: 22536899
PubMed Central: 3311103
Affiliations:
- Corée du Sud, États-Unis
- Californie, Indiana, Région capitale de Séoul
- Séoul
- Université nationale de Séoul
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A85
- to stream Pmc, to step Curation: 000A85
- to stream Pmc, to step Checkpoint: 001311
- to stream PubMed, to step Corpus: 001D86
- to stream PubMed, to step Curation: 001D86
- to stream PubMed, to step Checkpoint: 001D10
- to stream Ncbi, to step Merge: 000950
- to stream Ncbi, to step Curation: 000950
- to stream Ncbi, to step Checkpoint: 000950
- to stream Main, to step Merge: 002306
- to stream Main, to step Curation: 002281
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters</title><author><name sortKey="Yang, Youngik" sort="Yang, Youngik" uniqKey="Yang Y" first="Youngik" last="Yang">Youngik Yang</name><affiliation wicri:level="2"><nlm:aff id="I1">J Craig Venter Institute, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>J Craig Venter Institute, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nephew, Kenneth" sort="Nephew, Kenneth" uniqKey="Nephew K" first="Kenneth" last="Nephew">Kenneth Nephew</name><affiliation wicri:level="2"><nlm:aff id="I2">Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Kim, Sun" sort="Kim, Sun" uniqKey="Kim S" first="Sun" last="Kim">Sun Kim</name><affiliation wicri:level="4"><nlm:aff id="I3">School of Computer Science and Engineering, Bioinformatics Institute, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Computer Science and Engineering, Bioinformatics Institute, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22536899</idno><idno type="pmc">3311103</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311103</idno><idno type="RBID">PMC:3311103</idno><idno type="doi">10.1186/1471-2105-13-S3-S15</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000A85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A85</idno><idno type="wicri:Area/Pmc/Curation">000A85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A85</idno><idno type="wicri:Area/Pmc/Checkpoint">001311</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001311</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:22536899</idno><idno type="wicri:Area/PubMed/Corpus">001D86</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D86</idno><idno type="wicri:Area/PubMed/Curation">001D86</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D86</idno><idno type="wicri:Area/PubMed/Checkpoint">001D10</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D10</idno><idno type="wicri:Area/Ncbi/Merge">000950</idno><idno type="wicri:Area/Ncbi/Curation">000950</idno><idno type="wicri:Area/Ncbi/Checkpoint">000950</idno><idno type="wicri:Area/Main/Merge">002306</idno><idno type="wicri:Area/Main/Curation">002281</idno><idno type="wicri:Area/Main/Exploration">002281</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters</title><author><name sortKey="Yang, Youngik" sort="Yang, Youngik" uniqKey="Yang Y" first="Youngik" last="Yang">Youngik Yang</name><affiliation wicri:level="2"><nlm:aff id="I1">J Craig Venter Institute, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>J Craig Venter Institute, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nephew, Kenneth" sort="Nephew, Kenneth" uniqKey="Nephew K" first="Kenneth" last="Nephew">Kenneth Nephew</name><affiliation wicri:level="2"><nlm:aff id="I2">Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Kim, Sun" sort="Kim, Sun" uniqKey="Kim S" first="Sun" last="Kim">Sun Kim</name><affiliation wicri:level="4"><nlm:aff id="I3">School of Computer Science and Engineering, Bioinformatics Institute, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Computer Science and Engineering, Bioinformatics Institute, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></analytic><series><title level="j">BMC Bioinformatics</title><idno type="eISSN">1471-2105</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosomes, Human, Pair 21</term><term>CpG Islands</term><term>DNA Methylation</term><term>Down Syndrome (genetics)</term><term>Humans</term><term>Logistic Models</term><term>Models, Genetic</term><term>Neoplasms (genetics)</term><term>Promoter Regions, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chromosomes humains de la paire 21</term><term>Humains</term><term>Ilots CpG</term><term>Modèles génétiques</term><term>Modèles logistiques</term><term>Méthylation de l'ADN</term><term>Régions promotrices (génétique)</term><term>Syndrome de Down (génétique)</term><term>Tumeurs (génétique)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Down Syndrome</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Syndrome de Down</term><term>Tumeurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromosomes, Human, Pair 21</term><term>CpG Islands</term><term>DNA Methylation</term><term>Humans</term><term>Logistic Models</term><term>Models, Genetic</term><term>Promoter Regions, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chromosomes humains de la paire 21</term><term>Humains</term><term>Ilots CpG</term><term>Modèles génétiques</term><term>Modèles logistiques</term><term>Méthylation de l'ADN</term><term>Régions promotrices (génétique)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>DNA methylation is essential for normal development and differentiation and plays a crucial role in the development of nearly all types of cancer. Aberrant DNA methylation patterns, including genome-wide hypomethylation and region-specific hypermethylation, are frequently observed and contribute to the malignant phenotype. A number of studies have recently identified distinct features of genomic sequences that can be used for modeling specific DNA sequences that may be susceptible to aberrant CpG methylation in both cancer and normal cells. Although it is now possible, using next generation sequencing technologies, to assess human methylomes at base resolution, no reports currently exist on modeling cell type-specific DNA methylation susceptibility. Thus, we conducted a comprehensive modeling study of cell type-specific DNA methylation susceptibility at three different resolutions: CpG dinucleotides, CpG segments, and individual gene promoter regions.</p></sec><sec><title>Results</title><p>Using a k-mer mixture logistic regression model, we effectively modeled DNA methylation susceptibility across five different cell types. Further, at the segment level, we achieved up to 0.75 in AUC prediction accuracy in a 10-fold cross validation study using a mixture of k-mers.</p></sec><sec><title>Conclusions</title><p>The significance of these results is three fold: 1) this is the first report to indicate that CpG methylation susceptible "segments" exist; 2) our model demonstrates the significance of certain k-mers for the mixture model, potentially highlighting DNA sequence features (k-mers) of differentially methylated, promoter CpG island sequences across different tissue types; 3) as only 3 or 4 bp patterns had previously been used for modeling DNA methylation susceptibility, ours is the first demonstration that 6-mer modeling can be performed without loss of accuracy.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bird, A" uniqKey="Bird A">A Bird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Pa" uniqKey="Jones P">PA Jones</name></author><author><name sortKey="Laird, Pw" uniqKey="Laird P">PW Laird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ting, Ah" uniqKey="Ting A">AH Ting</name></author><author><name sortKey="Mcgarvey, Km" uniqKey="Mcgarvey K">KM McGarvey</name></author><author><name sortKey="Baylin, Sb" uniqKey="Baylin S">SB Baylin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herman, Jg" uniqKey="Herman J">JG Herman</name></author><author><name sortKey="Baylin, Sb" uniqKey="Baylin S">SB Baylin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costello, Jf" uniqKey="Costello J">JF Costello</name></author><author><name sortKey="Fruhwald, Mc" uniqKey="Fruhwald M">MC Frühwald</name></author><author><name sortKey="Smiraglia, Dj" uniqKey="Smiraglia D">DJ Smiraglia</name></author><author><name sortKey="Rush, Lj" uniqKey="Rush L">LJ Rush</name></author><author><name sortKey="Robertson, Gp" uniqKey="Robertson G">GP Robertson</name></author><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author><author><name sortKey="Wright, Fa" uniqKey="Wright F">FA Wright</name></author><author><name sortKey="Feramisco, Jd" uniqKey="Feramisco J">JD Feramisco</name></author><author><name sortKey="Peltom Ki, P" uniqKey="Peltom Ki P">P Peltomäki</name></author><author><name sortKey="Lang, Jc" uniqKey="Lang J">JC Lang</name></author><author><name sortKey="Schuller, De" uniqKey="Schuller D">DE Schuller</name></author><author><name sortKey="Yu, L" uniqKey="Yu L">L Yu</name></author><author><name sortKey="Bloomfield, Cd" uniqKey="Bloomfield C">CD Bloomfield</name></author><author><name sortKey="Caligiuri, Ma" uniqKey="Caligiuri M">MA Caligiuri</name></author><author><name sortKey="Yates, A" uniqKey="Yates A">A Yates</name></author><author><name sortKey="Nishikawa, R" uniqKey="Nishikawa R">R Nishikawa</name></author><author><name sortKey="Su Huang, H" uniqKey="Su Huang H">H Su Huang</name></author><author><name sortKey="Petrelli, Nj" uniqKey="Petrelli N">NJ Petrelli</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="O Dorisio, Ms" uniqKey="O Dorisio M">MS O'Dorisio</name></author><author><name sortKey="Held, Wa" uniqKey="Held W">WA Held</name></author><author><name sortKey="Cavenee, Wk" uniqKey="Cavenee W">WK Cavenee</name></author><author><name sortKey="Plass, C" uniqKey="Plass C">C Plass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laird, Pw" uniqKey="Laird P">PW Laird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feltus, Fa" uniqKey="Feltus F">FA Feltus</name></author><author><name sortKey="Lee, Ek" uniqKey="Lee E">EK Lee</name></author><author><name sortKey="Costello, Jf" uniqKey="Costello J">JF Costello</name></author><author><name sortKey="Plass, C" uniqKey="Plass C">C Plass</name></author><author><name sortKey="Vertino, Pm" uniqKey="Vertino P">PM Vertino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prufer, K" uniqKey="Prufer K">K Prüfer</name></author><author><name sortKey="Stenzel, U" uniqKey="Stenzel U">U Stenzel</name></author><author><name sortKey="Dannemann, M" uniqKey="Dannemann M">M Dannemann</name></author><author><name sortKey="Green, Re" uniqKey="Green R">RE Green</name></author><author><name sortKey="Lachmann, M" uniqKey="Lachmann M">M Lachmann</name></author><author><name sortKey="Kelso, J" uniqKey="Kelso J">J Kelso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccabe, Mt" uniqKey="Mccabe M">MT McCabe</name></author><author><name sortKey="Lee, Ek" uniqKey="Lee E">EK Lee</name></author><author><name sortKey="Vertino, Pm" uniqKey="Vertino P">PM Vertino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feltus, Fa" uniqKey="Feltus F">FA Feltus</name></author><author><name sortKey="Lee, Ek" uniqKey="Lee E">EK Lee</name></author><author><name sortKey="Costello, Jf" uniqKey="Costello J">JF Costello</name></author><author><name sortKey="Plass, C" uniqKey="Plass C">C Plass</name></author><author><name sortKey="Vertino, Pm" uniqKey="Vertino P">PM Vertino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keshet, I" uniqKey="Keshet I">I Keshet</name></author><author><name sortKey="Schlesinger, Y" uniqKey="Schlesinger Y">Y Schlesinger</name></author><author><name sortKey="Farkash, S" uniqKey="Farkash S">S Farkash</name></author><author><name sortKey="Rand, E" uniqKey="Rand E">E Rand</name></author><author><name sortKey="Hecht, M" uniqKey="Hecht M">M Hecht</name></author><author><name sortKey="Segal, E" uniqKey="Segal E">E Segal</name></author><author><name sortKey="Pikarski, E" uniqKey="Pikarski E">E Pikarski</name></author><author><name sortKey="Young, Ra" uniqKey="Young R">RA Young</name></author><author><name sortKey="Niveleau, A" uniqKey="Niveleau A">A Niveleau</name></author><author><name sortKey="Cedar, H" uniqKey="Cedar H">H Cedar</name></author><author><name sortKey="Simon, I" uniqKey="Simon I">I Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, L" uniqKey="Goh L">L Goh</name></author><author><name sortKey="Murphy, Sk" uniqKey="Murphy S">SK Murphy</name></author><author><name sortKey="Muhkerjee, S" uniqKey="Muhkerjee S">S Muhkerjee</name></author><author><name sortKey="Furey, Ts" uniqKey="Furey T">TS Furey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, F" uniqKey="Fang F">F Fang</name></author><author><name sortKey="Fan, S" uniqKey="Fan S">S Fan</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bock, C" uniqKey="Bock C">C Bock</name></author><author><name sortKey="Paulsen, M" uniqKey="Paulsen M">M Paulsen</name></author><author><name sortKey="Tierling, S" uniqKey="Tierling S">S Tierling</name></author><author><name sortKey="Mikeska, T" uniqKey="Mikeska T">T Mikeska</name></author><author><name sortKey="Lengauer, T" uniqKey="Lengauer T">T Lengauer</name></author><author><name sortKey="Walter, J" uniqKey="Walter J">J Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Handa, V" uniqKey="Handa V">V Handa</name></author><author><name sortKey="Jeltsch, A" uniqKey="Jeltsch A">A Jeltsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Rohde, C" uniqKey="Rohde C">C Rohde</name></author><author><name sortKey="Tierling, S" uniqKey="Tierling S">S Tierling</name></author><author><name sortKey="Jurkowski, Tp" uniqKey="Jurkowski T">TP Jurkowski</name></author><author><name sortKey="Bock, C" uniqKey="Bock C">C Bock</name></author><author><name sortKey="Santacruz, D" uniqKey="Santacruz D">D Santacruz</name></author><author><name sortKey="Ragozin, S" uniqKey="Ragozin S">S Ragozin</name></author><author><name sortKey="Reinhardt, R" uniqKey="Reinhardt R">R Reinhardt</name></author><author><name sortKey="Groth, M" uniqKey="Groth M">M Groth</name></author><author><name sortKey="Walter, J" uniqKey="Walter J">J Walter</name></author><author><name sortKey="Jeltsch, A" uniqKey="Jeltsch A">A Jeltsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunner, Al" uniqKey="Brunner A">AL Brunner</name></author><author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name></author><author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name></author><author><name sortKey="Valouev, A" uniqKey="Valouev A">A Valouev</name></author><author><name sortKey="Reddy, Te" uniqKey="Reddy T">TE Reddy</name></author><author><name sortKey="Neff, Nf" uniqKey="Neff N">NF Neff</name></author><author><name sortKey="Anton, E" uniqKey="Anton E">E Anton</name></author><author><name sortKey="Medina, C" uniqKey="Medina C">C Medina</name></author><author><name sortKey="Nguyen, L" uniqKey="Nguyen L">L Nguyen</name></author><author><name sortKey="Chiao, E" uniqKey="Chiao E">E Chiao</name></author><author><name sortKey="Oyolu, Cb" uniqKey="Oyolu C">CB Oyolu</name></author><author><name sortKey="Schroth, Gp" uniqKey="Schroth G">GP Schroth</name></author><author><name sortKey="Absher, Dm" uniqKey="Absher D">DM Absher</name></author><author><name sortKey="Baker, Jc" uniqKey="Baker J">JC Baker</name></author><author><name sortKey="Myers, Rm" uniqKey="Myers R">RM Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lister, R" uniqKey="Lister R">R Lister</name></author><author><name sortKey="Pelizzola, M" uniqKey="Pelizzola M">M Pelizzola</name></author><author><name sortKey="Dowen, Rh" uniqKey="Dowen R">RH Dowen</name></author><author><name sortKey="Hawkins, Rd" uniqKey="Hawkins R">RD Hawkins</name></author><author><name sortKey="Hon, G" uniqKey="Hon G">G Hon</name></author><author><name sortKey="Tonti Filippini, J" uniqKey="Tonti Filippini J">J Tonti-Filippini</name></author><author><name sortKey="Nery, Jr" uniqKey="Nery J">JR Nery</name></author><author><name sortKey="Lee, L" uniqKey="Lee L">L Lee</name></author><author><name sortKey="Ye, Z" uniqKey="Ye Z">Z Ye</name></author><author><name sortKey="Ngo, Qm" uniqKey="Ngo Q">QM Ngo</name></author><author><name sortKey="Edsall, L" uniqKey="Edsall L">L Edsall</name></author><author><name sortKey="Antosiewicz Bourget, J" uniqKey="Antosiewicz Bourget J">J Antosiewicz-Bourget</name></author><author><name sortKey="Stewart, R" uniqKey="Stewart R">R Stewart</name></author><author><name sortKey="Ruotti, V" uniqKey="Ruotti V">V Ruotti</name></author><author><name sortKey="Millar, Ah" uniqKey="Millar A">AH Millar</name></author><author><name sortKey="Thomson, Ja" uniqKey="Thomson J">JA Thomson</name></author><author><name sortKey="Ren, B" uniqKey="Ren B">B Ren</name></author><author><name sortKey="Ecker, Jr" uniqKey="Ecker J">JR Ecker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Kh" uniqKey="Taylor K">KH Taylor</name></author><author><name sortKey="Kramer, Rs" uniqKey="Kramer R">RS Kramer</name></author><author><name sortKey="Davis, Wj" uniqKey="Davis W">WJ Davis</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Duff, Dj" uniqKey="Duff D">DJ Duff</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name></author><author><name sortKey="Caldwell, Cw" uniqKey="Caldwell C">CW Caldwell</name></author><author><name sortKey="Shi, H" uniqKey="Shi H">H Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Paik, H" uniqKey="Paik H">H Paik</name></author><author><name sortKey="Nephew, K" uniqKey="Nephew K">K Nephew</name></author><author><name sortKey="Shi, H" uniqKey="Shi H">H Shi</name></author><author><name sortKey="Kramer, R" uniqKey="Kramer R">R Kramer</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name></author><author><name sortKey="Huang, Th" uniqKey="Huang T">TH Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Previti, C" uniqKey="Previti C">C Previti</name></author><author><name sortKey="Harari, O" uniqKey="Harari O">O Harari</name></author><author><name sortKey="Zwir, I" uniqKey="Zwir I">I Zwir</name></author><author><name sortKey="Val, Cd" uniqKey="Val C">CD Val</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiman, L" uniqKey="Breiman L">L Breiman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cormen, Th" uniqKey="Cormen T">TH Cormen</name></author><author><name sortKey="Leiserson, Ce" uniqKey="Leiserson C">CE Leiserson</name></author><author><name sortKey="Rivest, Rl" uniqKey="Rivest R">RL Rivest</name></author><author><name sortKey="Stein, C" uniqKey="Stein C">C Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Rohde, C" uniqKey="Rohde C">C Rohde</name></author><author><name sortKey="Tierling, S" uniqKey="Tierling S">S Tierling</name></author><author><name sortKey="Jurkowski, Tp" uniqKey="Jurkowski T">TP Jurkowski</name></author><author><name sortKey="Bock, C" uniqKey="Bock C">C Bock</name></author><author><name sortKey="Santacruz, D" uniqKey="Santacruz D">D Santacruz</name></author><author><name sortKey="Ragozin, S" uniqKey="Ragozin S">S Ragozin</name></author><author><name sortKey="Reinhardt, R" uniqKey="Reinhardt R">R Reinhardt</name></author><author><name sortKey="Groth, M" uniqKey="Groth M">M Groth</name></author><author><name sortKey="Walter, J" uniqKey="Walter J">J Walter</name></author><author><name sortKey="Jeltsch, A" uniqKey="Jeltsch A">A Jeltsch</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Californie</li><li>Indiana</li><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Yang, Youngik" sort="Yang, Youngik" uniqKey="Yang Y" first="Youngik" last="Yang">Youngik Yang</name></region><name sortKey="Nephew, Kenneth" sort="Nephew, Kenneth" uniqKey="Nephew K" first="Kenneth" last="Nephew">Kenneth Nephew</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Sun" sort="Kim, Sun" uniqKey="Kim S" first="Sun" last="Kim">Sun Kim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002281 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002281 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3311103
|texte= A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22536899" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |